Especially found in areas with dry soil, its leaves exude a milky juice when broken or pulled from the crown. It grows 1 – 5 feet tall from a deep taproot. The lower part of the stem is prickly or bristly, but it is nearly smooth toward the top. Pull or hoe seedlings, dig or pull larger plants before they set seed. Mulch around vegetables to prevent seeds already in the soil from germinating. Spot treat prickly lettuce with a product containing glufosinate-ammonium or glyphosate.